Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice

Author:

Smirnov Alexander V.ORCID,Kontsevaya Galina V.,Feofanova Natalia A.,Anisimova Margarita V.,Serova Irina A.,Gerlinskaya Lyudmila A.,Battulin Nariman R.,Moshkin Mikhail P.,Serov Oleg L.

Funder

Russian Science Foundation

Russian Academy of Sciences

Publisher

Springer Science and Business Media LLC

Subject

Agronomy and Crop Science,Genetics,Animal Science and Zoology,Biotechnology

Reference26 articles.

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2. Berglund EO, Murai KK, Fredette B, Sekerková G, Marturano B, Weber L, Mugnaini E, Ranscht B (1999) Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron 24:739–750. https://doi.org/10.1016/S0896-6273(00)81126-5

3. Buchner DA, Geisinger JM, Glazebrook PA, Morgan MG, Spiezio SH, Kaiyala KJ, Schwartz MW, Sakurai T, Furley AJ, Kunze DL, Croniger CM, Nadeau JH (2012) The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome 23:431–442. https://doi.org/10.1007/s00335-012-9400-8

4. Burkov IA, Serova IA, Battulin NR, Smirnov AV, Babkin IV, Andreeva LE, Dvoryanchikov GA, Serov OL (2013) Expression of the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene under control of the 5′-regulatory sequence of the goat alpha-S1-casein gene with and without a MAR element in transgenic mice. Transgenic Res 22:949–964. https://doi.org/10.1007/s11248-013-9697-4

5. Cain-Hom C, Splinter E, van Min M, Simonis M, van de Heijning M, Martinez M, Asghari V, Cox JC, Warming S (2017) Efficient mapping of transgene integration sites and local structural changes in Cre transgenic mice using targeted locus amplification. Nucleic Acids Res 45:e62. https://doi.org/10.1093/nar/gkw1329

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