Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation-Reference-Cited by-同舟云学术

Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation

Published:2016-04-21 Issue:5 Volume:25 Page:751-759
ISSN:0962-8819
Container-title:Transgenic Research
language:en
Short-container-title:Transgenic Res

Author:

Butler James R.,Martens Gregory R.,Estrada Jose L.,Reyes Luz M.,Ladowski Joseph M.,Galli Cesare,Perota Andrea,Cunningham Conor M.,Tector Matthew,Joseph Tector A.

Funder

Association for Academic Surgery

American Society of Transplant Surgeons (US)

Publisher

Springer Science and Business Media LLC

Subject

Agronomy and Crop Science,Genetics,Animal Science and Zoology,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11248-016-9958-0.pdf

Reference30 articles.

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2. Brunetti D, Perota A, Lagutina I, Colleoni S, Duchi R, Calabrese F, Seveso M, Cozzi E, Lazzari G, Lucchini F, Galli C (2008) Transgene expression of green fluorescent protein and germ line transmission in cloned pigs derived from in vitro transfected adult fibroblasts cloning and stem cells 10:409–419. doi: 10.1089/clo.2008.0036

3. Burlak C, Paris LL, Lutz AJ, Sidner RA, Estrada J, Li P, Tector M, Tector AJ (2014) Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 14:1895–1900. doi: 10.1111/ajt.12744

4. Butler JR, Ladowski JM, Martens GR, Tector M, Tector AJ (2015) Recent advances in genome editing and creation of genetically modified pigs. Int J Surg. doi: 10.1016/j.ijsu.2015.07.684

5. Byrne GW, McCurry KR, Martin MJ, McClellan SM, Platt JL, Logan JS (1997) Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 63:149–155

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