Abstract
Abstract“De novo” genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.
Funder
NSF-Simons QBio PhD Student Fellowship
Howard Hughes Medical Institute
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics
Cited by
26 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献