Effect of HDL1 infusion on biliary secretion in perfused rat liver-Reference-Cited by-同舟云学术

Effect of HDL1 infusion on biliary secretion in perfused rat liver

Published:1992-10-01 Issue:5 Volume:12 Page:425-432
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Rivabene Roberto¹,Cantafora Alfredo¹,Yan Chong Chao¹,Castellano Flavia²,Bruscalupi Giovannella²,Bravo Elena¹

Affiliation:

1. Istituto Superiore di Sanita', Laboratory of Metabolism and Pathological Biochemistry, Viale Regina Elena 299, 00161 Rome, Italy

2. Department of Cell and Developmental Biology, University La Sapienza, Rome, Italy

Abstract

The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in the in vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/12/5/425/468695/bsr0120425.pdf

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