New Insights of Biomarkers in IgE and Non-IgE-Mediated Drug Hypersensitivity-Reference-Cited by-同舟云学术

New Insights of Biomarkers in IgE and Non-IgE-Mediated Drug Hypersensitivity

Published:2019-02-01 Issue:1 Volume:6 Page:42-55
ISSN:2196-3053
Container-title:Current Treatment Options in Allergy
language:en
Short-container-title:Curr Treat Options Allergy

Author:

Mayorga Cristobalina,Muñoz-Cano R.,Rodríguez-Nogales A.,Fernandez-Santamaría R.,Fernandez T. D.

Publisher

Springer Science and Business Media LLC

Subject

Medicine (miscellaneous),Immunology and Allergy

Link

http://link.springer.com/content/pdf/10.1007/s40521-019-0201-0.pdf

Reference91 articles.

1. •• Pichler WJ, Hausmann O. Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms. Int Arch Allergy Immunol. 2016;171:166–79 A proposal of a new drug hypersensitivity reactions subclassification (beyond type A and B), combining time of appearance, phenotype/symptoms, possible immune pathomechanism, to obtain the mode of action involved in the specific DHR. Following this criteria, the authors suggest a new classification in allergic, pharmacological interaction with immune receptors (p-i ) and pseudoallergic reactions.

2. Bircher AJ, Scherer HK. Drug hypersensitivity reactions: inconsistency in the use of the classification of immediate and nonimmediate reactions. J Allergy Clin Immunol. 2012;129:263–4 author reply 265-266.

3. •• Torres MJ, Salas M, Ariza A, et al. Understanding the mechanisms in accelerated drug reactions. Curr Opin Allergy Clin Immunol. 2016;16:308–14 A review of the proposed mechanisms of accelerated urticarial and exanthematous reactions (between 1 and 24 h after drug exposure). The few works studying the underlyng mechanism suggest that most of these reactions are mediated by T cells, similar to those appearing in delayed reactions. However, an IgE-mediated mechanism cannot be ruled out, especially for some urticarial reactions, although literature shows that is not frequent.

4. Ariza A, Mayorga C, Fernandez TD, et al. Hypersensitivity reactions to beta-lactams: relevance of hapten-protein conjugates. J Investig Allergol Clin Immunol. 2015;25:12–25.

5. Levine BB. Immunologic mechanisms of penicillin allergy. A haptenic model system for the study of allergic diseases of man. N Engl J Med. 1966;275:1115–25.

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