Identification and kinetics of a ?-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan

Author:

Rivory Laurent P.,Robert Jacques

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference12 articles.

1. Fassberg J, Stella VJ (1992) A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 81:676

2. Gay C, Roche H, Chatelut E, Mathieu-Boué A, Canal P (1993) Excretion of irinotecan (CPT-11) and its metabolites in bile. Proceedings, Joint Symposium of the German Cancer Research Center, the EORTC PAMM and SPG groups and the AWO/Phase I/II-study groups of the German Cancer Society, Heidelberg, 1?4 December 1993

3. Gay C, Lokiec F, Canal P, Bonneterre J, Bugat R, Tubiana-Hulin M, Mathieu-Boué A (1994) Pharmacokinetics and pharmacodynamics of the camptothecin analogue CPT-11 during phase II studies. Proc Am Assoc Cancer Res 35:243

4. Kaneda N, Yokokura T (1990) Nonlinear kinetics of CPT-11 in rats. Cancer Res 50:1721

5. Kaneda N, Nagata H, Furuta T, Yokokura T (1990) Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res 50:1715

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