The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

Author:

Boddy Alan V.,Cole Michael,Pearson Andrew D. J.,Idle Jeffrey R.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference35 articles.

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2. Abramson FP (1986) Kinetic models of induction. II. Decreased turnover of a product or its prescursor. J Pharm Sci 75:229?232

3. Adamson PC, Boylan JF, Balis FM, Murphy RF, Godwin KA, Gudas LJ, Poplack DG (1993) Time course of induction of metabolism ofall-trans-retinoic acid and the up-regulation of cellular retinoic acid-binding protein. Cancer Res 53:472?476

4. Boddy AV, Idle JR (1992) Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma. J Chromatogr Biomed Appl 575:137?142

5. Boddy AV, Wyllie R, Price L, Pearson ADJ, Idle JR (1992) Increased clearance of ifosfamide in children during continuous infusion or repeated bolus administration. Pharm Res 9:S314

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