Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)-Reference-Cited by-同舟云学术

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Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)

Published:2019-02-11 Issue:3 Volume:20 Page:359-371
ISSN:1389-5729
Container-title:Biogerontology
language:en
Short-container-title:Biogerontology

Author:

Rolt Adam^ORCID,Nair Anitha,Cox Lynne S.^ORCID

Funder

Access Business Group

Biotechnology and Biological Sciences Research Council

Publisher

Springer Science and Business Media LLC

Subject

Geriatrics and Gerontology,Gerontology,Aging

Link

http://link.springer.com/article/10.1007/s10522-019-09796-4/fulltext.html

Reference31 articles.

1. Alimbetov D et al (2016) Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 17:305–315. https://doi.org/10.1007/s10522-015-9610-z

2. Baker DJ et al (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232–236. https://doi.org/10.1038/nature10600

3. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM (2016) Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530(7589):184–189. https://doi.org/10.1038/nature16932

4. Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM (2006) Cell Profiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol 7:R100

5. Childs BG, Durik M, Baker DJ, van Deursen JM (2015) Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med 21:1424–1435. https://doi.org/10.1038/nm.4000

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