Metabolism of the new nonbenzodiazepine anxiolytic agent, RWJ-51204, in mouse, rat, dog, monkey and human hepatic S9 fractions, and in rats, dogs and humans
-
Published:2004-12
Issue:4
Volume:29
Page:263-268
-
ISSN:0378-7966
-
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
-
language:en
-
Short-container-title:European Journal of Drug Metabolism and Pharmacokinetics
Author:
Wu W. N.,McKown L. A.,Reitz A. B.
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Reference10 articles.
1. Maryanoff, B.E., Ho, W., McComsey, D.F., Reitz, A.B., Grous, P.P, Nortey, S.O., Shank, R.P., Dubinsky, B., Taylor, Jr., R.J, Gardocki, J.F., (1995): Potential anxiolytic agents, pyrido[l,2-a]benzimidazole: anew structural class of ligands for the benzodiazepine binding site on GABA-A receptors, J. Med. Chem., 38,16–20. 2. Maryanoff, B.E., McComsey, D.F., Ho, W., Shank, R.P., and Dubinsky, B., (1996): Potential anxiolytic agents — II. Improvement of oral efficacy for the pyrido[l,2-a]benzimidazole (PBI) class of GABA-A receptor modulators, Bioorg. Med. Chem. Lett., 6, 333–338. 3. Reitz, A.B., Jordan, A.D., Sanfilippo, P.J., and Vavouyios-Smith, A., ( 1998): US Patent, 5,817,668,6. 4. Maryanoff, B.E., Nortey, S.O., McNally, J.J., Sanfilippo, P.J., McComsey, D.F., Dubinsky, B., Shank, R.P., and Reitz, A.B., (1999): Potential anxiolytic agents. 3. Novel A-ring modified pyrido[ 1,2-a]benzimidazole, Bioorg. Med. Chem. Lett., 9 1547–1552. 5. Scott, M.K., Demeter, D.A., Nortey, S.O., Dubinsky, B., Shank, R.P., and Reitz, A.B., (1999): 4 New directions in anxiolytic drug research, Prog. Med. Chem., 36,169–200.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|