Safety, Tolerability and Pharmacokinetics of Sugammadex Using Single High Doses (Up to 96 mg/kg) in Healthy Adult Subjects

Author:

Peeters Pierre A. M.,van den Heuvel Michiel W.,Heumen Emiel van,Passier Paul C. C. M.,Smeets Jean M. W.,van Iersel Thijs,Zwiers Alex

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Reference21 articles.

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3. Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 2002 Jan; 41(2): 266–70

4. Epemolu O, Bom A, Hope F, et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969. Anesthesiology 2003 Sept; 99(3): 632–7

5. deBoer HD, vanEgmond J, van de Pol F, et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology 2006 Apr; 104(4): 718–23

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