Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity
Author:
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Cell Biology,Toxicology
Link
https://link.springer.com/content/pdf/10.1007/s10565-022-09719-z.pdf
Reference33 articles.
1. Altun M, Zhao B, Velasco K, Liu H, Hassink G, Paschke J, Pereira T, Lindsten K. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia. J Biol Chem. 2012;287:1962–9.
2. Arturo EC, Gupta K, Hansen MR, Borne E, Jaffe EK. Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium. J Biol Chem. 2019;294:10131–45.
3. Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc Natl Acad Sci U S A. 2016;113:2394–9.
4. Aubi O, Prestegård KS, Jung-Kc K, Shi T-JS, Ying M, Grindheim AK, Scherer T, Ulvik A, McCann A, Spriet E. The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nat Commun. 2021;12:1–16.
5. Aubi O, Prestegård KS, Jung-Kc K, Shi TS, Ying M, Grindheim AK, Scherer T, Ulvik A, McCann A, Spriet E, et al. The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nat Commun. 2021;12:2073.
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1. CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis;Journal of Experimental & Clinical Cancer Research;2023-05-12
2. Hyperphenylalaninemias genotyping: Results of over 60 years of history in Lombardy, Italy;Endocrinology, Diabetes & Metabolism;2022-12-19
3. Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants;Scientific Reports;2022-08-20
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