Assessment of QT liabilities in drug development

Author:

Arrigoni C.,Crivori P.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Reference47 articles.

1. Abbott GW, Sesti F, Splawsky I, et al. MiRP1 forms I Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999;97:175–87.

2. Albengres E, Le Louet H, Tillement JP. Systemic antifungal agents. Drug interactions of clinical significance. Drug Safety. 1998;18(2):83–97.

3. Anonymous Committee for Proprietary Medicinal Products (CPMP) Points to Consider: The assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products. CPMP/986/96. 1997. [ http://www.emea.eu.int/home.htm ].

4. Anonymous. ICH S7A: Safety pharmacology studies for human pharmaceuticals (ICH step 5). CPMP/ICH/539/00. 2000. [ http://www.emea.eu.int/pdfs/human/ich/053900en.pdf ].

5. Anonymous. ICH S7B: The non-clinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals (ICH step 4). CHMP/ICH/432/02. 2005a. [ http://www.emea.eu.int/pdfs/human/ich/042302en.pdf ].

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