Clinico-histopathological review of 255 patients who underwent parotidectomy for pleomorphic adenoma: a 10-year retrospective study—a proposal for an optimal diagnostic and therapeutic algorithm for patients with recurrent pleomorphic adenoma

Author:

Zoccali Federica,Cialente FabrizioORCID,Colizza Andrea,Ralli Massimo,Greco Antonio,de Vincentiis Marco

Abstract

Abstract Purpose Pleomorphic adenoma (mixed tumor) is the most common neoplasm of the parotid gland and one of the most frequent types of salivary gland tumor, generally with benign behavior and relatively slow growing. The adenomas could arise from the superficial, deep or from both superficial and deep parotid’s lobes. Methods The aim of this review is to retrospectively analyze the surgical management of patients with pleomorphic adenoma of the parotid gland performed at the Department of Otorhinolaryngology (Department of Sense Organs of “Azienda Policlinico Umberto I” in Rome), from 2010 to 2020, with a focus on the percentage of recurrence and on the complication related to surgery to suggest an optimal diagnostic and therapeutic algorithm for patients with recurrent pleomorphic adenoma. The analysis of the complications observed in case of different surgical approaches was performed using the X2 test. Results The choice of a surgical approach (superficial parotidectomy—SP, total parotidectomy—TP, extracapsular dissection—ECD) depends on several elements, such as the location and the size of the adenoma, the availability of existing technical facilities and the professional experience of the surgeon. A transient facial palsy was present in 37.6%, 2.7% reported a permanent facial nerve palsy, 1.6% developed a salivary fistula, 1.6% a post-operative bleeding and 2.3% showed Frey Syndrome. Conclusion The surgical management of this benign lesion is required, even in asymptomatic cases, to prevent the progressive growing and to reduce the risk of malignant transformation. The goal of surgical excision is to obtain the complete resection to minimize the risk of tumor recurrence and avoiding facial nerve disability. Therefore, an accurate preoperative study of the lesion and the choice of the most appropriate surgical treatment are essential to minimize the rate of recurrence.

Funder

Università degli Studi di Roma La Sapienza

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Otorhinolaryngology

Reference22 articles.

1. Venkatesh S, Srinivas T, Hariprasad S (2019) Parotid gland tumors: 2-year prospective clinicopathological study. Ann Maxillofac Surg. 9(1):103–109. https://doi.org/10.4103/ams.ams_179_18. (PMID: 31293936; PMCID: PMC6585209)

2. Kanatas A, Ho MWS, Mücke T (2018) Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review. Br J Oral Maxillofac Surg 56(4):243–248. https://doi.org/10.1016/j.bjoms.2018.01.021. (Epub 2018 Mar 8; PMID: 29526342)

3. Rzepakowska A, Osuch-Wójcikiewicz E, Sobol M, Cruz R, Sielska-Badurek E, Niemczyk K (2017) The differential diagnosis of parotid gland tumors with high-resolution ultrasound in otolaryngological practice. Eur Arch Otorhinolaryngol 274(8):3231–3240. https://doi.org/10.1007/s00405-017-4636-2. (Epub 2017 Jun 13. PMID: 28612315; PMCID: PMC5500678)

4. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M (2010) Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg 68(9):2092–2098. https://doi.org/10.1016/j.joms.2009.09.075. (Epub 2010 Jun 17; PMID: 20728030)

5. Foresta E, Torroni A, Di Nardo F, de Waure C, Poscia A, Gasparini G, Marianetti TM, Pelo S (2014) Pleomorphic adenoma and benign parotid tumors: extracapsular dissection vs superficial parotidectomy–review of literature and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 117(6):663–676. https://doi.org/10.1016/j.oooo.2014.02.026. (Epub 2014 Mar 12; PMID: 24767698)

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