Abstract
Abstract
Purpose
Adenocarcinoma of the salivary glands is of low incidence and a broad range of histopathological subtypes. Cancer stem cell markers (CSC) might serve as novel prognostic parameters. To date, only a few studies examined the expression of CSC in adenocarcinoma of the salivary glands with diverging results. To further investigate the reliability in terms of prognostic value, a histopathological analysis of CSCs on a cohort of patients with adenocarcinomas of the major salivary glands was performed.
Methods
Tumor samples of 40 consecutive patients with adenocarcinoma of the major salivary gland treated with curative intend at one tertiary center were stained with the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2. Expression of these markers was correlated with clinicopathological parameters and survival estimates.
Results
Correlation of high expression of ALDH1 with higher grading (p < 0.001) and high expression of CD44 with the localization of the neoplasm (p = 0.05), larger tumor size (p = 0.006), positive pN-category (p = 0.023), and advanced UICC stage (p = 0.002) was found. Furthermore, high expression of SOX2 correlated with a negative perineural invasion (p = 0.02). No significant correlation of any investigated marker with survival estimates was observed.
Conclusion
In conclusion, our study did not find a significant correlation of the investigated CSCs with survival estimates in adenocarcinoma of the major salivary glands. Recapitulating the results of our study in conjunction with data in the literature, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not seem to serve as reliable prognostic parameters in the treatment of adenocarcinoma of the salivary glands.
Funder
Universitätsklinik München
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Otorhinolaryngology
Reference45 articles.
1. Barnes L, Eveson J, Reichart P, Sidransky D (2005) Tumours of the salivary glands. In: World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, France,
2. Leivo I (2006) Insights into a complex group of neoplastic disease: advances in histopathologic classification and molecular pathology of salivary gland cancer. Acta Oncol 45(6):662–668
3. Safdieh J, Givi B, Osborn V, Lederman A, Schwartz D, Schreiber D (2017) Impact of adjuvant radiotherapy for malignantsalivary gland tumors. Otolaryngol Head Neck Surg 157(6):988–994
4. Guzzo M, Locati L, Prott F, Gatta G, McGurk M (2010) Major and minor salivary gland tumors. Crit Rev Oncol Hematol 74(2):134–148
5. Lagha A, Chraiet N, Ayadi M, Krimi S, Allani B, Rifi H, Raies H, Mezlini A (2012) Systemic therapy in the management of metastatic or advanced salivary gland cancers. Head Neck Oncol 4(1):19
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献