Hormonal modulation of hepatic plasma membrane lactate transport in cultured rat hepatocytes-Reference-Cited by-同舟云学术

Hormonal modulation of hepatic plasma membrane lactate transport in cultured rat hepatocytes

Published:1990-12-01 Issue:6 Volume:10 Page:573-577
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Metcalfe H. K.,Cohen R. D.,Monson J. P.¹

Affiliation:

1. Cellular Mechanisms Group, London Hospital Medical College, London E1 2AD, UK

Abstract

Hormonal modulation of hepatic plasma membrane lactate transport was studied in primary cultures of isolated hepatocytes from fed rats to examine the mechanism for the known enhancement of lactate transport in starvation and diabetes. Total cellular lactate entry was increased by 14% in the presence of dexamethasone; this was accounted for by an approximately 40% increase in the carrier-mediated component of entry with no effect on diffusion. A trend of similar magnitude was evident with glucagon. The effects of dexamethasone and glucagon on lactate transport constitute an additional potential mechanism for enhancement of gluconeogenesis by these hormones.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/10/6/573/468265/bsr0100573.pdf

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