The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment

Author:

Cebra John J.,Logan Ava C.,Weinstein Peter D.

Publisher

Springer Science and Business Media LLC

Subject

Immunology

Reference6 articles.

1. Cebra JJ, Gearhart PJ, Halsey JF, Hurwitz JL, Shahin RD: Role of environmental antigens in the ontogeny of the secretory immune response. J Reticuloendothel Soc 1980;28S:61–71.

2. Kraal G, Weissman IL, Butcher EC: Germinal centre B cells: Antigen specificity and changes in heavy chain expression. Nature (London) 1982; 298:377–379.

3. London SD, Rubin DH, Cebra JJ: Gut mucosal immunization with reovirus serotype 1/L stimulates specific cytotoxic T-cell precursors as well as IgA memory cells in Peyer's patches. J Exp Med 1987;165:830–847.

4. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL: Surface phenotype of Peyer's patch germinal center cells: Implications for the role of germinal centers in B cell differentiation. J Immunol 1982;129:2698–2707.

5. Logan AC, Chow K-PN, George A, Weinstein PD, Cebra JJ: Peyer's patch and lymph node fragment cultures to compare local immune responses toMorganella morganii. Infect Immun 1991;59:1024–1031.

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