Abstract
Abstract
Purpose
Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare yet severe adverse event that requires rapid recognition and management. Diagnosing a definite case is challenging and involves meeting the American Thoracic Society (ATS) criteria, although alternative criteria have been suggested. This study aims to conduct a systematic review of literature and includes a case series.
Methods
Six cases of DIEP identified at Perugia Hospital, Perugia, Italy have been described. A systematic review was carried out adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines.
Results
a total of 74 cases of DIEP were analysed. Using ATS clinical criteria, 15 were classified as definite (20.3%), 54 as probable (73.0%), and 5 as possible (6.8%). Phillips criteria and the Lyon Algorithm identified 43/74 (58.2%) and 64/67 (95.5%) cases as definite, respectively. Bronchoalveolar lavage (BAL) was performed in 43 cases, revealing an average eosinophil count of 28.6% (SD 24.4). Radiological findings highlighted recurring features like bilateral opacities (68.1%), ground-glass opacities (41.7%), patchy infiltrates (30.6%), and peripheral predominance (19.4%). Upon suspicion, daptomycin was discontinued; 20 cases required no additional treatment, 38 received corticosteroids, and 12 received both corticosteroids and antibiotics. Recovery rates were high across all treatment types (≥ 73.7%). Most reports described rapid improvement post-withdrawal (within 96 h).
Conclusions
DIEP is a rare, fast-progressing condition where early diagnosis and prompt treatment are vital. Diagnosis relies on clinical, laboratory, and radiological evaluations. Stopping daptomycin is essential, with corticosteroids often necessary. Further research is needed to enhance diagnostic accuracy for this disease.
Funder
Università degli Studi di Perugia
Publisher
Springer Science and Business Media LLC
Reference61 articles.
1. Heidary M, Khosravi AD, Khoshnood S, Nasiri MJ, Soleimani S, Goudarzi M, Daptomycin. J Antimicrob Chemother. 2018;73:1–11.
2. Leone S, Noviello S, Boccia G, De Caro F, Esposito S. Methicillin-resistant Staphylococcus aureus infections: role of daptomycin/β-lactams combination. Le Infez Med [Internet]. 2015;23:99–104. http://www.ncbi.nlm.nih.gov/pubmed/26110289.
3. Di Carlo P, D’Alessandro N, Guadagnino G, Bonura C, Mammina C, Lunetta M et al. High dose of trimethoprim-sulfamethoxazole and daptomycin as a therapeutic option for MRSA endocarditis with large vegetation complicated by embolic stroke: a case report and literature review. Le Infez Med [Internet]. 2013;21:45–9. http://www.ncbi.nlm.nih.gov/pubmed/23524901.
4. Gidari A, Sabbatini S, Schiaroli E, Perito S, Francisci D, Baldelli F et al. Tedizolid-Rifampicin Combination Prevents Rifampicin-Resistance on in vitro Model of Staphylococcus aureus Mature Biofilm. Front Microbiol [Internet]. 2020;11. https://www.frontiersin.org/article/https://doi.org/10.3389/fmicb.2020.02085/full.
5. Patel JJ, Antony A, Herrera M, Lipchik RJ. Daptomycin-induced acute eosinophilic pneumonia. Wis Med J. 2014;113.