The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease

Abstract

AbstractChronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused byAspergillusin COPD namely invasive aspergillosis (IA), community-acquiredAspergilluspneumonia, chronic pulmonary Aspergillosis andAspergillussensitisation. Some of these entities are clearly linked to COPD, while others may coexist, but are less clearly liked directly to COPD. We discuss current uncertainties as these pertain to IA in COPD cohorts and explore areas for future research in this field.