The Role of Metastasectomy in Renal Cell Carcinoma in the Era of Targeted Therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Urology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11934-012-0293-6.pdf
Reference42 articles.
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3. Ljungberg B, Landberg G, Alamdari FI. Factors of importance for prediction of survival in patients with metastatic renal cell carcinoma, treated with or without nephrectomy. Scand J Urol Nephrol. 2000;34:246–51.
4. •• Coppin C, Kollmannsberger C, Le L, Porzsolt F, Wilt TJ. Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials. BJU Int 2011;108:1556–63. In this Cochrane systematic review, it was concluded that agents targeting VEGF and mTOR pathways improve PFS in both first-line and second-line settings. The authors found that the treatments rarely yield complete responses and thus are not curative. However, no placebo-controlled trial has reported a health-related quality of life benefit.
5. Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H, Crawford ED. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol. 2004;171:1071–6.
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