Evidence for and Against Liver Transplantation for Acute-on-Chronic Liver Failure
Author:
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology
Link
https://link.springer.com/content/pdf/10.1007/s11938-022-00380-3.pdf
Reference29 articles.
1. Moreau R Jalan R Gines P Pavesi M Angeli P Cordoba J Durand F Gustot T Saliba F Domenicali M Gerbes A. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013; https://doi.org/10.1053/j.gastro.2013.02.042
2. Sarin SK Choudhury A Sharma MK Maiwall R Al Mahtab M Rahman S Saigal S Saraf N Soin AS Devarbhavi H Kim DJ. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019; https://doi.org/10.1007/s12072-019-09946-3
3. Bajaj JS O'Leary JG Reddy KR Wong F Biggins SW Patton H Fallon MB Garcia‐Tsao G Maliakkal B Malik R Subramanian RM. Survival in infection‐related acute‐on‐chronic liver failure is defined by extrahepatic organ failures. Hepatology. 2014; https://doi.org/10.1002/hep.27077
4. Sundaram V Shah P Wong RJ Karvellas CJ Fortune BE Mahmud N Kuo A Jalan R. Patients with acute on chronic liver failure grade 3 have greater 14‐day waitlist mortality than status‐1a patients. Hepatology. 2019; https://doi.org/10.1002/hep.30624
5. • Belli LS, Duvoux C, Artzner T, Bernal W, Conti S, Cortesi PA, Sacleux SC, Pageaux GP, Radenne S, Trebicka J, Fernandez J. Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS). J Hepatology. 2021. https://doi.org/10.1016/j.jhep.2021.03.030. This multicenter retrospective study found that 1-year survival post-LT was 81%. Risk factors for post-LT mortality were elevated lactate levels, recent infection from multidrug-resistant organisms, and renal replacement therapy.
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