Prevention and treatment of NSAID-induced gastroduodenal injury

Author:

Lanas Angel

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology

Reference61 articles.

1. Hawkey CJ: Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000, 119: 521–535.

2. Bombardier C, Laine L, Reicin A, et al.: Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR study group. N Engl J Med 2000, 343: 1520–1528. This study showed that treatment with rofecoxib, 50 mg/d, was associated with reduced incidence of serious upper GI events and increased incidence of myocardial infarction when compared with naproxen, 500 mg twice daily, taken for a mean of 9 months.

3. Silverstein FE, Faich G, Goldstein JL, et al.: Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study. JAMA 2000, 284: 1247–1255. When compared with NSAIDs, high-dose celecoxib (400 mg twice daily) was associated with reduced incidence of upper GI complications in patients not taking low-dose aspirin. No differences were observed in patients taking low-dose aspirin.

4. Schnitzer TJ, Burmester GR, Mysler E, et al.: Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet 2004, 364: 665–674. When compared with nonselective NSAIDs, lumiracoxib, 400 mg/d, was associated with reduced incidence of upper GI complications. The differences were present in patients not taking low-dose aspirin, but there were no statistical differences in patients taking low-dose aspirin.

5. Lanas A, Panes J, Pique JM: Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. Curr Pharm Des 2003, 9: 2253–2266.

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