Current and Future Status for Evaluation of Dysplasia and Carcinoma in IBD

Author:

Kwah Joann,Farraye Francis A.

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology

Reference25 articles.

1. Wanders LK, Dekker E, Pullens B, et al. Cancer risk following resection of polypoid dysplasia in patients with long-standing ulcerative colitis: a meta-analysis. Clin Gastroenterol Hepatol. 2013. doi: 10.1016/j.cgh.2013.07.024 . This is a meta-analysis of 10 studies looking to identify the risk of cancer following endoscopic resection of polypoid dysplasia in patients with UC. The analysis shows that patients with UC have a low risk of CRC following resection of polypoid dysplasia, which supports current strategies of resection and surveillance, but that they do need to continue with close endoscopic follow-up, as they have a 10-fold greater risk of developing any dysplasia than CRC.

2. Jess T, Rungoe C, Peyrin-Biroulet L. Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol. 2012;10:639–45. This is a meta-analysis of 8 studies to determine the risk of CRC in patients with UC. It demonstrated that in population-based cohorts, an average of 1.6 % of patients with UC was diagnosed with CRC during 14 years of follow-up. Also, UC increases the risk of CRC by 2.4-fold. Male sex, young age at diagnosis of UC, and extensive colitis also increases the risk of CRC.

3. Rutter MD, Saunders BP, Wilkinson KH, et al. Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology. 2006;130:1030–8. This study looked at the value of colonoscopic surveillance for neoplasia in longstanding extensive UC. The study looked at data from a surveillance program over a 30-year period and found that colonoscopic surveillance was safe and allows the vast majority of patients to retain their colon.

4. Canavan C, Abrams KR, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther. 2006;23:1097–104. This meta-analysis was designed to ascertain the combined estimates of relative risk of Crohn’s disease with small bowel cancer and colorectal cancer. The study showed that the overall relative risk for CRC was elevated in Crohn’s disease at 2.5 (95 % CI, 1.3–4.7) that increased to 4.5 (95 % CI, 1.3-1.49) in patients with colonic disease.

5. Herrinton LJ, Liu L, Levin TR, et al. Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010. Gastroenterology. 2012;143(2):382–9. This study looks at the relationship between IBD and incidence and mortality of CRC among adults with intact colons in Northern California from 1998 to 2010. Using a large database, two sets of comparisons are made. The first is CRC incidence and mortality in IBD with CRC incidence and mortality in the general population. The second comparison is of IBD-related medications, partial colectomy, and CRC detection procedures in adults with IBD. Overall, the incidence rate of cancer for patients with IBD was higher than in the general population and was stable over time.

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