Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case–control study in Japan-Reference-Cited by-同舟云学术

Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case–control study in Japan

Published:2024-06-05 Issue: Volume: Page:
ISSN:0941-1291
Container-title:Surgery Today
language:en
Short-container-title:Surg Today

Author:

Sada Haruki,Hinoi Takao,Niitsu Hiroaki,Ohdan Hideki,Yamamoto Seiichiro,Endo Shungo,Hida Koya,Kinugasa Yusuke,Enomoto Toshiyuki,Maruyama Satoshi,Konishi Fumio,Watanabe Masahiko, ,Kanehira Eiji,Shiozawa Kunihisa,Bando Hiroyuki,Yamamoto Daisuke,Kitano Seigo,Inomata Masafumi,Akagi Tomonori,Okuda Junji,Tanaka Keitaro,Yasui Masayoshi,Hirakawa Kosei,Maeda Kiyoshi,Kanazawa Akiyoshi,Hasegawa Junichi,Nishimura Junichi,Akamoto Shintaro,Ueno Masashi,Kuroyanagi Hiroya,Naito Masaki,Ueki Takashi,Sakai Yoshiharu,Hida Koya,Kinjo Yousuke,Kokuba Yukihito,Hamada Madoka,Saito Norio,Ito Masaaki,Yamaguchi Shigeki,Tashiro Jou,Yatsuoka Toshimasa,Furuhata Tomohisa,Okita Kenji,Kubo Yoshiro,Saito Shuji,Kinugasa Yosuke,Konishi Fumio,Sakamoto Kazuhiro,Goto Michitoshi,Tanaka Junichi,Miyajima Nobuyoshi,Suda Tadashi,Shimamura Tsukasa,Saida Yoshihisa,Enomoto Toshiyuki,Naito Takeshi,Munakata Yasuhiro,Hayashi Ken,Takii Yasukimi,Maruyama Satoshi,Kurose Yohei,Miyake Yasuhiro,Hazama Shoichi,Fujii Shoich,Yamagishi Shigeru,Okajima Masazumi,Yamamoto Seiichiro,Horie Hisanaga,Murata Kohei,Sugihara Kenichi

Abstract

Abstract Purpose This study investigated the impact of sidedness of colorectal cancer (CRC) in elderly patients on the prognosis. Methods In a sub-analysis of a multicenter case–control study of CRC patients who underwent surgery at ≥ 80 years old conducted in Japan between 2003 and 2007, both short- and long-term outcomes were compared between right-sided colon cancers (RCCs) and left-sided colorectal cancers (LCCs). RCCs were defined as those located from the cecum to the transverse colon. Results Among the 1680 patients who underwent curative surgery, 812 and 868 had RCCs and LCCs, respectively. RCCs were more frequent than LCCs in those who were female, had renal comorbidities, and had a history of abdominal surgery. Regarding tumor characteristics, RCCs were larger, invaded more deeply, and were diagnosed as either mucinous or signet ring-cell carcinoma more frequently than LCCs. Regarding the prognosis, patients with RCCs had a significantly longer cancer-specific survival (CS-S) and cancer-specific relapse-free survival (CS-RFS) than those with LCCs. Furthermore, sidedness was determined to be an independent prognostic factor for CS-S and CS-RFS. Conclusion RCCs, which accounted for half of the cases in patients ≥ 80 years old, showed better long-term outcomes than LCCs.

Funder

Hiroshima University

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s00595-024-02827-9.pdf

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