Abstract
Abstract
Purpose
Intracranial aneurysm (IA) wall enhancement on post-contrast vessel wall magnetic resonance imaging (VW-MRI) is assumed to be a biomarker for vessel wall inflammation and aneurysm instability. However, the exact factors contributing to enhancement are not yet clarified. This study investigates the relationship between luminal enhancement and intra-aneurysmal flow behaviour to assess the suitability of VW-MRI as a surrogate method for determining quantitative and qualitative flow behaviour in the aneurysm sac.
Methods
VW-MRI signal is measured in the lumen of three patient-specific IA flow models and compared with the intra-aneurysmal flow fields obtained using phase-contrast magnetic resonance imaging (PC-MRI) and computational fluid dynamics (CFD). The IA flow models were supplied with two different time-varying flow regimes.
Results
Overall, the velocity fields acquired using PC-MRI or CFD were in good agreement with the VW-MRI enhancement patterns. Generally, the regions with slow-flowing blood show higher VW-MRI signal intensities, whereas high flow leads to a suppression of the signal. For all aneurysm models, a signal value above three was associated with velocity values below three cm/s.
Conclusion
Regions with lower enhancements have been correlated with the slow and high flow at the same time. Thus, further factors like flow complexity and stability can contribute to flow suppression in addition to the flow magnitude. Nevertheless, VW-MRI can qualitatively assess intra-aneurysmal flow phenomena and estimate the velocity range present in the corresponding region.
Funder
Deutsche Forschungsgemeinschaft
European Structural and Investment Funds
Research Training Group "Materials4Brain"
Bundesministerium für Bildung und Forschung
Otto-von-Guericke-Universität Magdeburg
Publisher
Springer Science and Business Media LLC
Subject
Health Informatics,Radiology, Nuclear Medicine and imaging,General Medicine,Surgery,Computer Graphics and Computer-Aided Design,Computer Science Applications,Computer Vision and Pattern Recognition,Biomedical Engineering
Reference35 articles.
1. Wiebers DO (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. The Lancet 362(9378):103–110
2. Etminan N, Rinkel GJ (2016) Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol 12(12):699
3. Cebral JR, Detmer F, Chung BJ, Choque-Velasquez J, Rezai B, Lehto H, Tulamo R, Hernesniemi J, Niemela M, Yu A (2019) Local hemodynamic conditions associated with focal changes in the intracranial aneurysm wall. Am J Neuroradiol 40(3):510–516
4. Leemans EL, Cornelissen BMW, Said M, Rvd B, Slump CH, Marquering HA, Majoie CBLM (2019) Intracranial aneurysm growth: consistency of morphological changes. Neurosurg Focus FOC 47(1):E5. https://doi.org/10.3171/2019.4.FOCUS1987
5. Leemans EL, Cornelissen BMW, Slump CH, Majoie CBLM, Cebral JR, Marquering HA (2019) Comparing morphology and hemodynamics of stable-versus-growing and grown intracranial aneurysms. Am J Neuroradiol 40(12):2102–2110. https://doi.org/10.3174/ajnr.A6307
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献