Author:
Pisárčik Martin,Bajcura Martin,Lukáč Miloš,Devínsky Ferdinand,Bilková Andrea,Bilka František,Horváth Branislav
Abstract
AbstractSynthesis, aggregation parameters and antimicrobial activity of novel cationic gemini surfactants with two amide groups in gemini spacer structure and a variable number of carbon atoms in alkyl tails ranging from 12 to 15 are reported. The critical micelle concentration of gemini surfactants was determined using surface tension and electrical conductivity methods. The cmc values were found in the range 0.83 to 0.06 mM. The interfacial area, micelle ionisation degree and the Gibbs free energy per molecule and alkyl chain were calculated from the surface tension and conductivity curves. Particle size analysis using the dynamic light scattering method confirmed the formation of small spherical micelles 6–7 nm large in size for gemini surfactants with 12 and 13 carbon atoms in the alkyl chain. A large size above 50 nm was found for the aggregates composed of long-chain gemini molecules with 14 and 15 carbon atoms. The zeta potential of gemini surfactants shows a continuous increase with the increasing alkyl chain length. Micelle aggregation number of gemini surfactants correlates well with the hydrodynamic size data. Small aggregation number values were found for short-chain gemini molecules with 12 and 13 carbon atoms in the alkyl chain. Long-chain gemini molecules with 14 and 15 carbon atoms exhibit aggregate growth represented by an increase in the aggregation number values while maintaining the spherical or spheroidal shape of micelles. The investigations of antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and yeast indicate the increasing antimicrobial efficiency towards the short-chain surfactant with 12 carbon atoms in the alkyl chain. A possible cut-off effect presence is proposed to explain the dependence of antimicrobial activity on the surfactant alkyl tail length.
Funder
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
Agentúra na Podporu Výskumu a Vývoja
Comenius University in Bratislava
Publisher
Springer Science and Business Media LLC
Subject
Materials Chemistry,Colloid and Surface Chemistry,Polymers and Plastics,Physical and Theoretical Chemistry