New Horizons for Cholesterol Ester Transfer Protein Inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11883-011-0217-9.pdf
Reference46 articles.
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2. Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362:1563–74.
3. Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849–61.
4. Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 2005;366:1279–89.
5. •• Thompson A, Di AE, Sarwar N, et al. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA 2008, 299:2777–2788. This important meta-analysis of 46 case-control studies, involving more than 80,000 subjects, demonstrates that polymorphisms of CETP associated with lower activity and higher HDL-C concentration are also associated with lower coronary risk. The results lend support to the hypothesis that pharmacologic CETP inhibition may be therapeutically useful.
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