Oral Lipid-Lowering Treatments Beyond Statins: Too Old and Outdated or Still Useful?

Author:

Parhofer Klaus G.

Abstract

Abstract Purpose of Review For many years, the lipid-lowering armamentarium consisted of statins and/or ezetimibe and/or bile acid sequestrants and/or fibrates. Now, with the availability of new drugs mostly injectables, the field has changed and the role of oral non-statin drugs (including bempedoic acid) must be reevaluated. Recent Findings Ezetimibe remains a very important combination partner for statins with continuously increasing treatment numbers. Bempedoic acid is another interesting combination partner for statin/ezetimibe or ezetimibe alone but lacks in contrast to ezetimibe evidence from outcome trials. The role of fibrates is less clear as they have shown disappointing results in outcome trials but may still be used in selected, high-risk patients with combined dyslipidemia. Bile acid sequestrants are now rarely used as there are stronger, better tolerable ways to lower LDL-cholesterol. Summary With the introduction of new injectable lipid-lowering drugs, some oral drugs such as ezetimibe and bempedoic acid still have an important spot in our treatment algorithm others such as fibrates have a less clear role while again others are now rarely used.

Funder

Ludwig-Maximilians-Universität München

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Moderne Strategien zur Lipidsenkung – die frühe Kombinationstherapie;Zeitschrift für Herz-,Thorax- und Gefäßchirurgie;2024-05

2. Pharmacotherapies for Cardiovascular Disease Prevention;Preventive Cardiovascular Nursing;2024

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