Tumor-derived cytokines induce bone marrow suppressor cells that mediate immunosuppression through transforming growth factor β

Author:

Young M. Rita I.,Wright Mark A.,Coogan Michael,Young Melvin E.,Bagash Jamila

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Reference29 articles.

1. Awwad M, North RJ (1989) Cyclophosphamide-induced immunologically mediated regression of a cyclophosphamide-resistant murine tumor: a consequence of eliminating precursor L3T4+ suppressor T-cells. Cancer Res 49: 1649

2. Brooks B, Chapman K, Lawry J, Meager A, Rees RC (1990) Suppression of lymphokine-activated killer (LAK) cell induction mediated by interleukin-4 and transforming growth factor-β1. effect of addition of exogenous tumour necrosis factor-alpha and interferongamma, and measurement of their endogenous production. Clin Exp Immunol 82: 583

3. Chakraborty NG, Twardzik DR, Sivanandham M, Ergin MT, Hellstrom KE, Mukherji B (1990) Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response. J Immunol 145: 2359

4. Clark DA, Falbo M, Rowley RB, Banwatt D, Stedronska-Clark J (1988) Active suppression of host-vs-graft reaction in pregnant mice: IX. Soluble suppressor activity obtained from allopregnant mouse decidua that blocks the cytolytic effector response to IL-2 is related to transforming growth factor-β. J Immunol 141: 3833

5. Cleveland MG, Lane RG, Klimpel GR (1988) Spontaneous IFN-beta production. A common feature of natural suppressor systems. J Immunol 141: 2043

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