Abstract
AbstractMost studies on arsenic toxicity have been conducted among populations exposed to arsenic contained in drinking water. Relatively little research concerns effects of airborne arsenic. The aim of this study was to determine whether there is an association between urinary 15-F2t-isoprostane (u15-F2t-IsoP) levels in relation to renal function (urinary creatinine and N-acetyl-β-d-glucosaminidase––uNAG) and urinary arsenic (uAs) in inhabitants from copper smelter impact zone. The secondary purpose of the analysis was to assess utility of a potential association between uAs and u15-F2t-IsoP as a biomarker of systemic oxidative stress. Urinary 15-F2t-IsoP, NAG, and creatinine were measured in 967 urine samples collected from 649 adult women (51.9 ± 13.2 years old) and 318 adult men (53.8 ± 14.9 years old). Total uAs concentration was measured in 918 samples using HPLC-ICP-MS. Arsenic species, such as inorganic arsenic, methylarsonic acid, dimethylarsinic acid, and arsenobetaine, were measured in urine collected from 255 participants with uAs exceeding the upper norm. Data were analyzed using multivariate linear regression and logistic regression models. In the studied population urinary creatinine was positively associated with uAs. A positive linear correlation (p < 0.0000) between lg(uAs) and u15-F2t-IsoP was found both for normal and elevated uAs. A positive linear correlation was observed also between lg(ΣuAs) and u15-F2t-IsoP (p < 0.0000). In the logistic regression model, after adjustment for confounders, elevated uAs was the only predictor of increased u15-F2t-IsoP (OR = 1.31, 95% CI 1.08–1.59, p < 0.01). Cigarette smoking was associated with renal proximal tubular dysfunction only in people with uNAG concentration above 75th quartile. In the studied population chronically exposed to airborne arsenic, increase in urinary arsenic is associated with renal dysfunction and systemic oxidative stress. Urinary 15-F2t-isoprostane may be useful in the monitoring of health status in populations exposed to airborne arsenic.
Funder
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,Water Science and Technology
Reference54 articles.
1. Agency for Toxic Substances Disease Registry (ATSDR) (2007) Toxicological Profile for Arsenic. U. S. Department of Health and Human Services, Public Health Service, Atlanta
2. Agirbasli M, Radhakrishnamurthy B, Jiang X, Bao W, Berenson GS (1996) Urinary N-acetyl-β-d-glucosaminidase changes in relation to age, sex, race, and diastolic and systolic blood pressure in a young adult biracial population The Bogalusa heart study. Am J Hypertension 9:157–161
3. Air quality in Europe 2015 report. European Environment Agency. EEA Report No 5/2015 http://www.eea.europa.eu/publications/air-quality-in-europe-2015/download
4. Bedir A, Ozener IC, Emerk K (1996) Urinary leucine aminopeptidase is a more sensitive indicator of early renal damage in non-insulin-dependent diabetics than microalbuminuria. Nephron 74:110–113
5. Che-Jung C, D’Souza P, Ryan P, Dana B (2018) The precision and accuracy of urinary creatinine analysis for correction of urine dilution in biological monitoring measurements. ISEE Conf Abstr. https://doi.org/10.1289/isesisee.2018.P01.2670
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献