Amino acid composition of human liver mitochondrial membranes in normal and pathological conditions-Reference-Cited by-同舟云学术

Amino acid composition of human liver mitochondrial membranes in normal and pathological conditions

Published:1991-04-01 Issue:2 Volume:11 Page:95-100
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Benga Gheorghe¹,Hodârnău Adriana²,Tilinca Rozalia²,Borza Victoria²,Ferdinand William³

Affiliation:

1. Department of Cell and Molecular Biology, University of Medicine and Pharmacy Cluj-Napoca, 6 Pasteur St., 3400 Cluj-Napoca

2. Department of Biochemistry, University of Medicine and Pharmacy Cluj-Napoca, 6 Pasteur St., 3400 Cluj-Napoca

3. Department of Biochemistry, University of Sheffield, UK

Abstract

The amino acid composition of proteins from liver mitochondrial membranes has been studied in patients with normal liver, with biliary diseases and fatty liver, with obstructive jaundice or liver cirrhosis. A characteristic pattern of the amino acid composition in patients with normal liver has been found. In the mitochondrial membranes of patients with fatty liver tryptophan and lysine were decreased while [aspartic acid plus asparagine] and [glutamic acid plus glutamine] were increased compared to their counterpart in the normal liver. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in methionine content was found, while in the case of liver cirrhosis amino acid composition was markedly changed.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/11/2/95/468378/bsr0110095.pdf

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