Abstract
Abstract
Purpose
To review the neuro-cognitive complications of nephropathic cystinosis.
Methods
Review of published information on neurological and cognitive complications of cystinosis.
Results
Nephropathic cystinosis is a rare disorder of cystine metabolism. Although renal failure is the earliest and most severe complication of this condition, all organs of the body eventually become involved. The brains of children with cystinosis demonstrate structural changes early in life. Neuro-cognitive differences, including motor incoordination and visual spatial dysfunction, are present from early life and may negatively impact learning. Executive functioning is also impaired and this may contribute to poor adherence to medication regimens.
Conclusions
Early recognition of these difficulties allows for intervention to minimize problems associated with the neurocognitive deficits in cystinosis.
Publisher
Springer Science and Business Media LLC
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