Abstract
AbstractVitiligo is acquired depigmentation due to multiple factors. Vitamin D in skin, through its receptors (VDR), regulates cell growth, differentiation, immune response and exerts both stimulatory and protective effects on melanocytes. The gene sequence encoding VDR has polymorphic forms such as ApaI and TaqI that may affect vitamin D actions. Narrowband ultraviolet B (NB-UVB) phototherapy became the mainstay of vitiligo treatment because of its efficacy and little side effects. The current work aimed at evaluating the possible association between VDR gene polymorphisms (TaqI and ApaI) and susceptibility of vitiligo and if they could be predictors of response to NB-UVB phototherapy in Egyptian vitiligo patients. 100 vitiligo patients indicated for NB-UVB phototherapy and 100 healthy age and sex matched controls were included. All participants were subjected to history taking, general and dermatological examinations, and VDR ApaI and TaqI gene polymorphisms analysis by PCR–RFLP. The patients received NB-UVB 3times per week for 6 months then revaluated. There was significant increase in Aa genotype of ApaI polymorphism in patients associated with significant increase in vitiligo activity. 66% of patient showed variable degrees of response to NB-UVB. The responders significantly had AA genotype of ApaI polymorphism. TaqI polymorphism showed nonsignificant effects on vitiligo susceptibility and response to NB-UVB. A allele of ApaI was significant independent predictor of NB-UVB phototherapy responders. VDR gene polymorphism (ApaI) may share in vitiligo pathogenesis and response to NB-UVB. Knowing the genetic background of the patient helps individualization of treatment to get better results.
Publisher
Springer Science and Business Media LLC
Subject
Dermatology,General Medicine
Reference44 articles.
1. Kruger C, Schallreuter KU (2012) A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Int J Dermatol 51:1206–1212
2. Boniface K, Seneschal J, Picardo M et al (2018) Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy. Clin Rev Allergy Immunol 54(1):52–67
3. Uitterlinden AG, Fang Y, Van Meurs JB et al (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143–156
4. Sehrawat M, Arora TC, Chauhan A et al (2014) Correlation of vitamin D levels with pigmentation in vitiligo patients treated with NBUVB therapy. ISRN Dermatol 23:493213
5. Awad S, Morsy H, Abdel-Aal A et al (2016) Effect of narrowband ultraviolet B phototherapy on serum vitamin D levels in patients with vitiligo. J Egypt Women Dermatol Soc 13(1):37–42
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献