Efficacy and safety of botulinum toxin in treating scleroderma-associated raynaud’s phenomenon: a systematic review and meta-analysis

Author:

Elrosasy Amr,Abo Zeid Mohamed,cadri Shirin,Fahmy Belal M.,Elzeftawy Mohamed A.,Mohammed Fatma,Ramadan Alaa

Funder

Science and Technology Development Fund

Publisher

Springer Science and Business Media LLC

Reference9 articles.

1. Cappelli L, Wigley FM (Aug. 2015) Management of Raynaud Phenomenon and Digital Ulcers in Scleroderma. Rheumatic Disease Clin North Am 41(3):419–438. https://doi.org/10.1016/j.rdc.2015.04.005

2. Medina S et al (2018) Botulinum toxin type A in the treatment of Raynaud’s phenomenon: A three-year follow-up study, Eur J Rheumatol, vol. 5, no. 4, pp. 224–229, https://doi.org/10.5152/eurjrheum.2018.18013Fiakos G, Kuang Z, Lo E. Improved skin regeneration with acellular fish skin grafts. Engineered Regeneration. 2020;1:95–101. doi:10.1016/j.engreg.2020.09.002

3. Neumeister MW et al (2009) Botox Therapy for Ischemic Digits, Plast Reconstr Surg, vol. 124, no. 1, pp. 191–201, doi: 10.1097/PRS.0b013e3181a80576.Lima Júnior EM, Moraes Filho MO de, Forte AJ,. Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study. Journal of Burn Care & Research. Published online August 26, 2019. https://doi.org/10.1093/jbcr/irz149

4. Ennis D, Ahmad Z, Anderson MA, Johnson SR, Botulinum toxin in the management of primary and secondary Raynaud’s phenomenon, (2021) https://doi.org/10.1016/j.berh.2021.101684.W. Du, M. Zhou, C. Zhang, and Q. Sun, The efficacy of botulinum toxin A in the treatment of Raynaud’s phenomenon in systemic sclerosis: A randomized self-controlled trial, Dermatol Ther, vol. 35, no. 7, Jul. 2022, doi: 10.1111/dth.15529

5. Du W, Zhou M, Zhang C, Sun Q (Jul. 2022) The efficacy of botulinum toxin A in the treatment of Raynaud’s phenomenon in systemic sclerosis: a randomized self-controlled trial. Dermatol Ther 35(7). https://doi.org/10.1111/dth.15529

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