Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers

Author:

Kamei Hiroyuki,Isaji Ami,Noda Yukihiro,Ishikawa Kazuhiro,Senzaki Koji,Yamada Kiyofumi,Sugiura Kazumitsu,Tomita Yasushi,Nabeshima Toshitaka

Publisher

Springer Science and Business Media LLC

Subject

Dermatology,General Medicine

Reference41 articles.

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2. Chen C, Hanson E, Watson JW, Lee JS (2003) P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 31:312–318

3. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866–871

4. Enomoto T, Lu HQ, Yin M, Sakoda T, Dake Y, Enomoto K, Ide T, Cheng L (2009) Evaluation of the efficacy and safety of olopatadine and fexofenadine compared with placebo in Japanese cedar pollinosis using an environmental exposure unit. J Investig Allergol Clin Immunol 19:299–305

5. Fujita K, Magara H, Kobayashi H (1999) Determination of olopatadine, a new antiallergic agent, and its metabolites in human plasma by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 731:345–352

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