Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (?)-methylphenobarbital

Author:

Bohn W.,Ullrich V.,Staudinger Hj.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference30 articles.

1. Alvares, A. P., Schilling, G., Levin, W., Kuntzmann, R.: Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene. Biochem. biophys. Res. Commun.29, 521 (1967).

2. Bidleman, K., Mannerring, G. J.: Induction of drug metabolism V. Independent formation of cytochromes P-450 and P1-450 in rats treated with phenobarbital and 3-methylcholanthrene simultaneously. Molec. Pharmacol.6, 697 (1970).

3. Büch, H., Buzello, W., Neurohr, O., Rummel, W.: Vergleich von Verteilung, narkotischer Wirksamkeit und metabolischer Elimination der optischen Antipoden von Methylphenobarbital. Biochem. Pharmacol.17, 2391 (1968).

4. ?, Grund, W., Buzello, W., Rummel, W.: Narkotische Wirksamkeit und Gewebsverteilung der optischen Antipoden des Pentobarbitals bei der Ratte. Biochem. Pharmacol.18, 1005 (1969).

5. ?, Knabe, J., Buzello, W., Rummel, W.: Stereospecificity of anesthetic activity, distribution, inactivation, and protein binding of the optical antipodes of two N-methylated barbiturates. J. Pharmacol. exp. Ther.175, 705 (1970).

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