An experiment in enzyme evolution studies with Pseudomonas aeruginosa amidase

Author:

Clarke Patricia H.12,Drew Robert1

Affiliation:

1. Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK

2. Glebe House, School Hill, Cirencester, Gloucestershire GL7 2LS

Abstract

The regulation of amidase synthesis in P. aeruginosa is under positive control. This review describes the experimental evolution of amidase and its regulator protein for the hydrolysis of novel substrates and experiments to elucidate the mechanism of the control system.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference41 articles.

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2. Jacob, F. and Monod J. (1961).J. Mol. Biol. 3:318.

3. Holloway, B. W. (1955).J. Gen. Microbiol. 13:572.

4. Den Dooren de Jong., L. E. (1925).Bijdrage tot de kennis van het mineralsatiesproces, Dissertation, Rotterdam.

5. Clarke, P. H. and Meadow, P. W. (1959).J. Gen. Microbiol. 20:144.

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