Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Author:

Winnik Stephan,Gaul Daniel S.,Preitner Frédéric,Lohmann Christine,Weber Julien,Miranda Melroy X.,Liu Yilei,Tits Lambertus J.,Mateos José María,Brokopp Chad E.,Auwerx Johan,Thorens Bernard,Lüscher Thomas F.,Matter Christian M.

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference43 articles.

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2. Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WPT, Loria CM, Smith SC (2009) Harmonizing the Metabolic Syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645. doi: 10.1161/CIRCULATIONAHA.109.192644

3. Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Magiolini M, Feraco E, Mari V, Franceschi C, Passarino G, De Benidictis G (2005) A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85:258–263. doi: 10.1016/j.ygeno.2004.11.003

4. Chen Y, Zhang J, Lin Y, Lei Q, Guan K-L, Zhao S, Xiong Y (2011) Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 12:534–541. doi: 10.1038/embor.2011.65

5. Cimen H, Han M-J, Yang Y, Tong Q, Koc H, Koc EC (2010) Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry 49:304–311. doi: 10.1038/embor.2011.65

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