Integration of epigenetic regulatory mechanisms in heart failure

Author:

Sopic Miron,Robinson Emma L.,Emanueli Costanza,Srivastava Prashant,Angione Claudio,Gaetano Carlo,Condorelli Gianluigi,Martelli Fabio,Pedrazzini Thierry,Devaux YvanORCID,

Abstract

AbstractThe number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.

Funder

Ministry of Education, Science and Technological Development, Republic of Serbia

European Union

American Heart Association

Colorado Clinical and Translational Sciences Institute

Alan Turing Institute

Ricerca Corrente - Rete cardiologica IRCCS

Italian Ministry of Health

Italian Cardiology Network IRCCS

Telethon Foundation

AFM-Telethon

EU Horizon 2020

cardioRNA COST action

Fonds National de la Recherche Luxembourg

CardioRNA COST action

Ministère de l'Enseignement Supérieur et de la Recherche

Heart Foundation—Daniel Wagner of Luxembourg

Regione Lombardia

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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