Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

Author:

An Rui,Zhao Lei,Xi Cong,Li Haixun,Shen Guohong,Liu Haixiao,Zhang Shumiao,Sun Lijun

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference130 articles.

1. Adi N, Mash DC, Ali Y, Singer C, Shehadeh L, Papapetropoulos S (2010) Melatonin MT1 and MT2 receptor expression in Parkinson’s disease. Med Sci Monit 16:BR61–BR67

2. Agil A, Reiter RJ, Jimenez-Aranda A, Iban-Arias R, Navarro-Alarcon M, Marchal JA, Adem A, Fernandez-Vazquez G (2013) Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. J Pineal Res 54:381–388. doi: 10.1111/jpi.12012

3. Ali T, Kim MO (2015) Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3beta pathway in the mouse hippocampus. J Pineal Res. doi: 10.1111/jpi.12238

4. Amin AH, El-Missiry MA, Othman AI (2015) Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis. Eur J Pharmacol 747:166–173. doi: 10.1016/j.ejphar.2014.12.002

5. Andersson U, Tracey KJ (2003) HMGB1 in sepsis. Scand J Infect Dis 35:577–584

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