Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

Author:

Gadicherla Ashish Kumar,Wang Nan,Bulic Marco,Agullo-Pascual Esperanza,Lissoni Alessio,De Smet Maarten,Delmar Mario,Bultynck Geert,Krysko Dmitri V.,Camara Amadou,Schlüter Klaus-Dieter,Schulz Rainer,Kwok Wai-Meng,Leybaert LucORCID

Funder

Fund for Scientific Research Flanders, Belgium

Bijzonder onderzoeksfonds, Universiteit Gent

Interuniversity Attraction Poles Program

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference86 articles.

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2. Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Liang F-X, Li Z, Pfenniger A, Lubkemeier I, Keegan S, Fenyo D, Willecke K, Rothenberg E, Delmar M (2014) Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc. Cardiovasc Res 104:371–381. doi: 10.1093/cvr/cvu195

3. Aldakkak M, Camara AKS, Heisner JS, Yang M, Stowe DF (2011) Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res 64:381–392. doi: 10.1016/j.phrs.2011.06.018

4. Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, Camara AKS (2008) Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release. Cardiovasc Res 77:406–415. doi: 10.1016/j.cardiores.2007.08.008

5. Azarashvili T, Baburina Y, Grachev D, Krestinina O, Evtodienko Y, Stricker R, Reiser G (2011) Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43. Am J Physiol Cell Physiol 300:C707–C720. doi: 10.1152/ajpcell.00061.2010

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