Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury

Author:

Wang Junzhuo,Chen Ziwei,Dai Qing,Zhao Jinxuan,Wei Zilun,Hu Jiaxin,Sun Xuan,Xie JunORCID,Xu Biao

Funder

the Natural Science Foundation of China

the Funds for Jiangsu Provincial Key Medical Discipline

the Key Projects of Science and Techology of Jiangsu Province

the Programs of the Science Foundation in Nanjing

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference39 articles.

1. Afzal MR, Samanta A, Shah ZI, Jeevanantham V, Abdel-Latif A, Zuba-Surma EK, Dawn B (2015) Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials. Circ Res 117:558–575. https://doi.org/10.1161/CIRCRESAHA.114.304792

2. Ansboro S, Roelofs AJ, De Bari C (2017) Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both? Curr Opin Rheumatol 29:201–207. https://doi.org/10.1097/BOR.0000000000000370

3. Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J (2003) Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108:863–868. https://doi.org/10.1161/01.CIR.0000084828.50310.6A

4. Bekkers SC, Yazdani SK, Virmani R, Waltenberger J (2010) Microvascular obstruction: underlying pathophysiology and clinical diagnosis. J Am Coll Cardiol 55:1649–1660. https://doi.org/10.1016/j.jacc.2009.12.037

5. Carrick D, Haig C, Ahmed N, McEntegart M, Petrie MC, Eteiba H, Hood S, Watkins S, Lindsay MM, Davie A, Mahrous A, Mordi I, Rauhalammi S, Sattar N, Welsh P, Radjenovic A, Ford I, Oldroyd KG, Berry C (2016) Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction: relation to microvascular obstruction and prognostic significance. Circ Cardiovasc Imaging 9:e004148. https://doi.org/10.1161/CIRCIMAGING.115.004148

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