Theophylline inhibits platelet aggregation, prostaglandin and thromboxane production by a mechanism which is independent of cyclic AMP

Author:

Burns Gillian B.,Dodge J. A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Toxicology,Pharmacology,Immunology

Reference14 articles.

1. M.L. Steer andE.W. Salzman, Cyclic nucleotides in haemostasis and thrombosis. InAdvances in Cyclic Nucleotide Research, vol. 12, pp. 71–92 (Eds.P. Hamet andH. Sands). Raven Press, New York 1980.

2. J.M. Gerrard, J.D. Peller, T.P. Krick andJ.G. White,Cyclic AMP and platelet prostaglandin synthesis, Prostaglandins14, 30–51 (1977).

3. C. Malmsten, E. Granstrom andB. Samuelsson,Cyclic AMP inhibits the synthesis of prostaglandin endoperoxide (PGG 2)in human platelets, Biochem. biophys. Res. Commun.68, 569–576 (1976).

4. J.A. Lindgren, H.E. Claesson, H. Kindahl andS. Hammarstrom, Effects of platelet aggregation and adenosine 3′,5′-monophosphate on the synthesis of thromboxane B2 in human platelets. InAdvances in Prostaglandin and Thromboxane Research, vol. 6, pp. 275–281 (Eds.B. Samuelsson, P.W. Ramwell andR. Paoletti). Raven Press, New York 1980.

5. M. Minkes, N. Stanford, M.M. Chi, G.J. Roth, A. Raz, P. Needleman andP.W. Majerus,Cyclic adenosine 3′,5′-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions, J. clin. Invest.59, 449–454 (1977).

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