Dipeptidyl Peptidase-4 Inhibitors and Heart Failure: Friends or Foes?-Reference-Cited by-同舟云学术

Dipeptidyl Peptidase-4 Inhibitors and Heart Failure: Friends or Foes?

Published:2015-05-29 Issue:8 Volume:9 Page:
ISSN:1932-9520
Container-title:Current Cardiovascular Risk Reports
language:en
Short-container-title:Curr Cardiovasc Risk Rep

Author:

Monami Matteo,Mannucci Edoardo

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s12170-015-0465-2.pdf

Reference83 articles.

1. McMurray JJ, Petrie MC, Murdoch DR, Davie AP. Clinical epidemiology of heart failure: public and private health burden. Eur Heart J. 1998;19(Suppl P):P9–16. Heart failure is one of the leading causes of morbidity and mortality and its prevalence continues to rise.

2. Levy D et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347:1397–402. Before the publication of the SAVOR-TIMI53 trial, available data suggested that DPP4 inhibitors could have a protective effect with respect to heart failure.

3. Schocken DD, Arrieta MI, Leaverton PE, Ross EA. Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol. 1992;20:301–6. The risk of hospitalization for HF with saxagliptin, compared to placebo, in the SAVOR-TIMI53 study was about 26%.

4. Roger VL et al. Trends in heart failure incidence and survival in a community-based population. JAMA. 2004;292:344–50. The possible mechanisms underlying the association of DPP4i with HF include: a) reduction of GLP1 [9-36]; b) increase of brain natriuretic peptide; c) increase of neuropeptide Y and substance P.

5. Fonarow GC et al. Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med. 2008;168:847–54. Available experimental and clinical data are insufficient to provide a clear picture of causal relationships between DPP4 inhibition and signs and symptoms of HF.

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