Glial Factors Regulating White Matter Development and Pathologies of the Cerebellum

Author:

Revuelta Miren,Scheuer Till,Chew Li-Jin,Schmitz ThomasORCID

Abstract

AbstractThe cerebellum is a brain region that undergoes extremely dynamic growth during perinatal and postnatal development which is regulated by the proper interaction between glial cells and neurons with a complex concert of growth factors, chemokines, cytokines, neurotransmitters and transcriptions factors. The relevance of cerebellar functions for not only motor performance but also for cognition, emotion, memory and attention is increasingly being recognized and acknowledged. Since perturbed circuitry of cerebro-cerebellar trajectories can play a role in many central nervous system pathologies and thereby contribute to neurological symptoms in distinct neurodevelopmental and neurodegenerative diseases, is it the aim with this mini-review to highlight the pathways of glia–glia interplay being involved. The designs of future treatment strategies may hence be targeted to molecular pathways also playing a role in development and disease of the cerebellum.

Funder

Deutsche Forschungsgemeinschaft

Institute of Education, University and Research of the Basque Government

Förderverein für Frühgeborene Kinder an der Charité e.V.

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,General Medicine,Biochemistry

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