Abstract
AbstractTo the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.
Funder
H2020 Marie Skłodowska-Curie Actions
Università degli Studi dell'Insubria
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,General Medicine,Biochemistry
Reference154 articles.
1. Woolf SH (2008) The meaning of translational research and why it matters. JAMA 299:211–213. https://doi.org/10.1001/jama.2007.26
2. Nichio BTL, Marchaukoski JN, Raittz RT (2017) New tools in orthology analysis: a brief review of promising perspectives. Front Genet 8:165. https://doi.org/10.3389/fgene.2017.00165
3. Fox JG, Bennett BT (2015) Chapter 1 - Laboratory animal medicine: historical perspectives. In: Fox JG, Anderson LC, Otto GM, Pritchett-Corning KR, Whary MT (eds) Laboratory animal medicine, 3rd edn. Academic Press, Boston, pp 1–21
4. Lobert VH, Mouradov D, Heath JK (2016) Focusing the spotlight on the zebrafish intestine to illuminate mechanisms of colorectal cancer. Adv Exp Med Biol 916:411–437
5. Khan KM, Collier AD, Meshalkina DA, Kysil EV, Khatsko SL, Kolesnikova T, Morzherin YY, Warnick JE, Kalueff AV, Echevarria DJ (2017) Zebrafish models in neuropsychopharmacology and CNS drug discovery. Br J Pharmacol 174:1925–1944. https://doi.org/10.1111/bph.13754
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献