Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”
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Published:2022-08-16
Issue:3
Volume:10
Page:125-154
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ISSN:2167-4841
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Container-title:Current Pediatrics Reports
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language:en
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Short-container-title:Curr Pediatr Rep
Author:
Felín Mariangela Soberón, Wang Kanix, Moreira Aliya, Grose Andrew, Leahy Karen, Zhou Ying, Clouser Fatima Alibana, Siddiqui Maryam, Leong Nicole, Goodall Perpetua, Michalowski Morgan, Ismail Mahmoud, Christmas Monica, Schrantz Stephen, Caballero Zuleima, Norero Ximena, Estripeaut Dora, Ellis David, Raggi Catalina, Castro Catherine, Moossazadeh Davina, Ramirez Margarita, Pandey Abhinav, Ashi Kevin, Dovgin Samantha, Dixon Ashtyn, Li Xuan, Begeman Ian, Heichman Sharon, Lykins Joseph, Villalobos-Cerrud Delba, Fabrega Lorena, Montalvo José Luis Sanchez, Mendivil Connie, Quijada Mario R., Fernández-Pirla Silvia, de La Guardia Valli, Wong Digna, de Guevara Mayrene Ladrón, Flores Carlos, Borace Jovanna, García Anabel, Caballero Natividad, Rengifo-Herrera Claudia, de Saez Maria Theresa Moreno, Politis Michael, Ross Stephanie, Dogra Mimansa, Dhamsania Vishan, Graves Nicholas, Kirchberg Marci, Mathur Kopal, Aue Ashley, Restrepo Carlos M., Llanes Alejandro, Guzman German, Rebellon Arturo, Boyer Kenneth, Heydemann Peter, Noble A. Gwendolyn, Swisher Charles, Rabiah Peter, Withers Shawn, Hull Teri, Frim David, McLone David, Su Chunlei, Blair Michael, Latkany Paul, Mui Ernest, Vasconcelos-Santos Daniel Vitor, Villareal Alcibiades, Perez Ambar, Galvis Carlos Andrés Naranjo, Montes Mónica Vargas, Perez Nestor Ivan Cardona, Ramirez Morgan, Chittenden Cy, Wang Edward, Garcia-López Laura Lorena, Padrieu Guillermo, Muñoz-Ortiz Juliana, Rivera-Valdivia Nicolás, Bohorquez-Granados María Cristina, de-la-Torre Gabriela Castaño, Hernandez Juan David Valencia, Celis-Giraldo Daniel, Dávila Juan Alejandro Acosta, Torres Elizabeth, Oquendo Manuela Mejia, Arteaga-Rivera José Y., Nicolae Dan L, Rzhetsky Andrey, Roizen Nancy, Stillwaggon Eileen, Sawers Larry, Peyron Francois, Wallon Martine, Chapey Emanuelle, Levigne Pauline, Charter Carmen, De Frias Migdalia, Montoya Jose, Press Cindy, Ramirez Raymund, Contopoulos-Ioannidis Despina, Maldonado Yvonne, Liesenfeld Oliver, Gomez Carlos, Wheeler Kelsey, Zehar Samantha, McAuley James, Limonne Denis, Houze Sandrine, Abraham Sylvie, Piarroux Raphael, Tesic Vera, Beavis Kathleen, Abeleda Ana, Sautter Mari, El Mansouri Bouchra, El Bachir Adlaoui, Amarir Fatima, El Bissati Kamal, Holfels Ellen, Frim David, McLone David, Penn Richard, Cohen William, de-la-Torre Alejandra, Britton Gabrielle, Motta Jorge, Ortega-Barria Eduardo, Romero Isabel Luz, Meier Paul, Grigg Michael, Gómez-Marín Jorge, Kosagisharaf Jagannatha Rao, Llorens Xavier Sáez, Reyes Osvaldo, McLeod RimaORCID
Abstract
Abstract
Purpose of Review
Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health.
Recent Findings
Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work.
Summary
Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference139 articles.
1. •• Mcleod R, Mack DG, Boyer K, Mets M, Roizen N, Swisher C, Patel D, Beckmann E, Vitullo D, Johnson D, et al. Phenotypes and functions of lymphocytes in congenital toxoplasmosis. J Lab Clin Med. 1990;116(5):623–35 Parasite specific unresponsiveness in tests of cell mediated immunity in US children with congenital toxoplasmosis. 2. McGee T, Wolters C, Stein L, Kraus N, Johnson D, Boyer K, Mets M, Roizen N, Beckman J, Meier P, Swisher C, Holfels E, Withers S, McLeod R. Absence of sensorineural hearing loss in treated infants and children with congenital toxoplasmosis. Otolaryngol Head Neck Surg. 1992;106(1):75–80 Identifies that in the US in treated children sensorineural hearing loss is very rare. 3. •• Mcleod R, Mack D, Foss R, Boyer K, Withers S, Levin S, Hubbell J. Levels of pyrimethamine in sera and cerebrospinal and ventricular fluids from infants treated for congenital toxoplasmosis. Toxoplasmosis Study Group. Antimicrob Agents Chemother. 1992;36(5):1040–8 Presents pyrimethamine pharmacokinetics in infants and children and that treatment can be used safely in the first year as well. Outcomes for some children were markedly better than for comparable children in the literature. 4. •• McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, Wolters C, Stein L, Stein M, Schey W, Remington J, Meier P, Johnson D, Heydemann P, Holfels E, Withers S, Mack D, Brown C, Patton D, McLeod R. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis. 1994;18(1):38–72 Systematic follow up of treated and untreated children and the beginning of a randomized treatment study is described. 5. •• Swisher CN, Boyer K, McLeod R. Congenital toxoplasmosis. In: Bodensteiner JB (ed). Sem Ped Neurol, 1994;1:4-25. Describes neurologic findings of congenital toxoplasmosis in the United States.
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