Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview
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Published:2022-08-22
Issue:3
Volume:10
Page:57-92
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ISSN:2167-4841
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Container-title:Current Pediatrics Reports
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language:en
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Short-container-title:Curr Pediatr Rep
Author:
Felín Mariangela Soberón, Wang Kanix, Moreira Aliya, Grose Andrew, Leahy Karen, Zhou Ying, Clouser Fatima Alibana, Siddiqui Maryam, Leong Nicole, Goodall Perpetua, Michalowski Morgan, Ismail Mahmoud, Christmas Monica, Schrantz Stephen, Caballero Zuleima, Norero Ximena, Estripeaut Dora, Ellis David, Raggi Catalina, Castro Catherine, Moossazadeh Davina, Ramirez Margarita, Pandey Abhinav, Ashi Kevin, Dovgin Samantha, Dixon Ashtyn, Li Xuan, Begeman Ian, Heichman Sharon, Lykins Joseph, Villalobos-Cerrud Delba, Fabrega Lorena, Montalvo José Luis Sanchez, Mendivil Connie, Quijada Mario R., Fernández-Pirla Silvia, de La Guardia Valli, Wong Digna, de Guevara Mayrene Ladrón, Flores Carlos, Borace Jovanna, García Anabel, Caballero Natividad, Rengifo-Herrera Claudia, de Saez Maria Theresa Moreno, Politis Michael, Wroblewski Kristen, Karrison Theodore, Ross Stephanie, Dogra Mimansa, Dhamsania Vishan, Graves Nicholas, Kirchberg Marci, Mathur Kopal, Aue Ashley, Restrepo Carlos M., Llanes Alejandro, Guzman German, Rebellon Arturo, Boyer Kenneth, Heydemann Peter, Noble A. Gwendolyn, Swisher Charles, Rabiah Peter, Withers Shawn, Hull Teri, Su Chunlei, Blair Michael, Latkany Paul, Mui Ernest, Vasconcelos-Santos Daniel Vitor, Villareal Alcibiades, Perez Ambar, Galvis Carlos Andrés Naranjo, Montes Mónica Vargas, Perez Nestor Ivan Cardona, Ramirez Morgan, Chittenden Cy, Wang Edward, Garcia-López Laura Lorena, Muñoz-Ortiz Juliana, Rivera-Valdivia Nicolás, Bohorquez-Granados María Cristina, de-la-Torre Gabriela Castaño, Padrieu Guillermo, Hernandez Juan David Valencia, Celis-Giraldo Daniel, Dávila Juan Alejandro Acosta, Torres Elizabeth, Oquendo Manuela Mejia, Arteaga-Rivera José Y., Nicolae Dan L., Rzhetsky Andrey, Roizen Nancy, Stillwaggon Eileen, Sawers Larry, Peyron Francois, Wallon Martine, Chapey Emanuelle, Levigne Pauline, Charter Carmen, De Frias Migdalia, Montoya Jose, Press Cindy, Ramirez Raymund, Contopoulos-Ioannidis Despina, Maldonado Yvonne, Liesenfeld Oliver, Gomez Carlos, Wheeler Kelsey, Holfels Ellen, Frim David, McLone David, Penn Richard, Cohen William, Zehar Samantha, McAuley James, Limonne Denis, Houze Sandrine, Abraham Sylvie, Piarroux Raphael, Tesic Vera, Beavis Kathleen, Abeleda Ana, Sautter Mari, El Mansouri Bouchra, El Bachir Adlaoui, Amarir Fatima, El Bissati Kamal, de-la-Torre Alejandra, Britton Gabrielle, Motta Jorge, Ortega-Barria Eduardo, Romero Isabel Luz, Meier Paul, Grigg Michael, Gómez-Marín Jorge, Kosagisharaf Jagannatha Rao, Llorens Xavier Sáez, Reyes Osvaldo, McLeod RimaORCID
Abstract
AbstractPurpose of ReviewReview building of programs to eliminateToxoplasmainfections.Recent FindingsMorbidity and mortality from toxoplasmosis led to programs in USA, Panama, and Colombia to facilitate understanding, treatment, prevention, and regional resources, incorporating student work.SummaryStudies foundational for building recent, regional approaches/programs are reviewed. Introduction provides an overview/review of programs in Panamá, the United States, and other countries. High prevalence/risk of exposure led to laws mandating testing in gestation, reporting, and development of broad-based teaching materials aboutToxoplasma.These were tested for efficacy as learning tools for high-school students, pregnant women, medical students, physicians, scientists, public health officials and general public. Digitized, free, smart phone application effectively taught pregnant women about toxoplasmosis prevention. Perinatal infection care programs, identifying true regional risk factors, and point-of-care gestational screening facilitate prevention and care. When implemented fully across all demographics, such programs present opportunities to save lives, sight, and cognition with considerable spillover benefits for individuals and societies.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference154 articles.
1. •• Mcleod R, Mack DG, Boyer K, Mets M, Roizen N, Swisher C, Patel D, Beckmann E, Vitullo D, Johnson D, et al. Phenotypes and functions of lymphocytes in congenital toxoplasmosis. J Lab Clin Med. 1990;116(5):623–35 Parasite specific unresponsiveness in tests of cell mediated immunity in US children with congenital toxoplasmosis. 2. McGee T, Wolters C, Stein L, Kraus N, Johnson D, Boyer K, Mets M, Roizen N, Beckman J, Meier P, Swisher C, Holfels E, Withers S, McLeod R. Absence of sensorineural hearing loss in treated infants and children with congenital toxoplasmosis. Otolaryngol Head Neck Surg. 1992;106(1):75–80 Identifies that in the US in treated children sensorineural hearing loss is very rare. 3. •• Mcleod R, Mack D, Foss R, Boyer K, Withers S, Levin S, Hubbell J. Levels of pyrimethamine in sera and cerebrospinal and ventricular fluids from infants treated for congenital toxoplasmosis. Toxoplasmosis Study Group. Antimicrob Agents Chemother. 1992;36(5):1040–8 Presents pyrimethamine pharmacokinetics in infants and children and that treatment can be used safely in the first year of life. Outcomes for some children were markedly better than for comparable children in prior literature. 4. •• McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, Wolters C, Stein L, Stein M, Schey W, Remington J, Meier P, Johnson D, Heydemann P, Holfels E, Withers S, Mack D, Brown C, Patton D, McLeod R. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis. 1994;18(1):38–72 Systematic diagnosis and follow up of treated and untreated children and the beginning of a randomized treatment study. 5. •• Swisher CN, Boyer K, McLeod R. Congenital toxoplasmosis. In JB Bodensteiner, Ed. Semin Pediatr Neurol. 1994;1:4–25 Describes neurologic findings of congenital toxoplasmosis in the United States.
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