Discovery of novel DGAT1 inhibitors by combination of machine learning methods, pharmacophore model and 3D-QSAR model-Reference-Cited by-同舟云学术

Discovery of novel DGAT1 inhibitors by combination of machine learning methods, pharmacophore model and 3D-QSAR model

Published:2021-06-23 Issue:3 Volume:25 Page:1481-1495
ISSN:1381-1991
Container-title:Molecular Diversity
language:en
Short-container-title:Mol Divers

Author:

Zhang Hui,Shen Chen,Zhang Hong-Rui,Chen Wen-Xuan,Luo Qing-Qing,Ding Lan

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Link

https://link.springer.com/content/pdf/10.1007/s11030-021-10247-x.pdf

Reference36 articles.

1. Motiwala H, Kandre S, Birar V, Kadam KS, Rodge A, Jadhav RD, Mahesh Kumar Reddy M, Brahma MK, Deshmukh NJ, Dixit A, Doshi L, Gupte A, Gangopadhyay AK, Vishwakarma RA, Srinivasan S, Sharma M, Nemmani KV, Sharma R (2011) Exploration of pyridine containing heteroaryl analogs of biaryl ureas as dgat1 inhibitors. Bioorg Med Chem Lett 21:5812–5817. https://doi.org/10.1016/j.bmcl.2011.07.109

2. Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J (2014) Discovery of novel quinoline carboxylic acid series as dgat1 inhibitors. Bioorg Med Chem Lett 24:1790–1794. https://doi.org/10.1016/j.bmcl.2014.02.028

3. Haslam DW, James WP (2005) Obesity. Lancet 366:1197–1209. https://doi.org/10.1016/S0140-6736(05)67483-1

4. Li L, Liu DW, Yan HY, Wang ZY, Zhao SH, Wang B (2016) Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies. Obes Rev 17:510–519. https://doi.org/10.1111/obr.12407

5. Kennedy EP (1956) The synthesis of cytidine diphosphate choline, cytidine diphosphate ethanolamine, and related compounds. J Biol Chem 222:185–191. https://doi.org/10.1016/S0021-9258(19)50784-0

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanism of emergency phytoremediation technology based on a 3D-QSAR pharmacological model;Frontiers in Plant Science;2024-08-26

2. Inhibitory effects of bromoindoles on Escherichia coli O157:H7 biofilms;Biotechnology and Bioprocess Engineering;2024-04-18

3. Structure-guided Design and Optimization of small Molecules as Pancreatic Lipase Inhibitors using Pharmacophore, 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation Studies;Current Computer-Aided Drug Design;2023-08

4. A machine learning-integrated stepwise method to discover novel anti-obesity phytochemicals that antagonize the glucocorticoid receptor;Food & Function;2023

5. Natural products from plants targeting key enzymes for the future development of antidiabetic agents;Natural Product Reports;2023