Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists

Published:2018-07-04 Issue:1 Volume:23 Page:19-33
ISSN:1381-1991
Container-title:Molecular Diversity
language:en
Short-container-title:Mol Divers

Author:

Nian Si-Yun,Wang Guo-Ping,Jiang Zheng-Li,Xiao Ying,Huang Mo-Han,Zhou Yi-Huan,Tan Xiang-Duan

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Link

http://link.springer.com/article/10.1007/s11030-018-9843-2/fulltext.html

Reference21 articles.

1. Jin J, Sun X, Zhao Z, Wang W, Qiu Y, Fu X, Huang M, Huang Z (2015) Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine 22:894–901. https://doi.org/10.1016/j.phymed.2015.06.007

2. Yang L, Broderick D, Campbell Y, Gombart AF, Stevens JF, Jiang Y, Hsu VL, Bisson WH, Maier CS (2016) Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies. Biochim Biophys Acta 1864:1667–1677. https://doi.org/10.1016/j.bbapap.2016.08.019

3. Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A (2014) Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation. Curr Top Med Chem 14:2159–2574. https://doi.org/10.2174/1568026614666141112100208

4. Song K, Xu X, Liu P, Chen L, Shen X, Liu J, Hu L (2015) Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists. Bioorg Med Chem 23:6427–6436. https://doi.org/10.1016/j.bmc.2015.08.021

5. Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A (2014) Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands. Curr Top Med Chem 14:2129–2142. https://doi.org/10.2174/1568026614666141112094058

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation;European Journal of Medicinal Chemistry;2024-04

2. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment;European Journal of Medicinal Chemistry;2020-07

3. Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism;European Journal of Medicinal Chemistry;2019-11