Quantitative and qualitative models for carcinogenicity prediction for non-congeneric chemicals using CP ANN method for regulatory uses

Author:

Fjodorova Natalja,Vračko Marjan,Tušar Marjan,Jezierska Aneta,Novič Marjana,Kühne Ralph,Schüürmann Gerrit

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Reference98 articles.

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2. OECD (2002) Guidance notes for analysis and evaluation of chronic toxicity and carcinogenicity studies. OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 35, Paris, France

3. Combes RD (2000) The use of structure-activity relationships and markers of cell toxicity to detect non-genotoxic carcinogens. Toxicol In Vitro 14: 387–399. doi: 10.1016/S0887-2333(00)00026-6

4. Choy WN (2001) Genotoxic and non-genotoxic mechanisms of carcinogenesis. In: Choy WN (eds) Genetic toxicology and cancer risk assessment. Marcel Dekker, New York, pp 47–72

5. Combes R, Grindon C, Cronin MTD, Roberts DW, Garrod JF (2007) Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH Legislation. ATLA 35: 267–287

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